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It also feeds into the GABA shunt, an alternative metabolic pathway that produces Gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter

Because xylazine has a different mechanism of action compared to opioids and other psychoactive drugs, it may produce synergistic effects (e.g

Cycling protocols (8 weeks on, 4 weeks off) are designed around this adaptation curve